The Mines II boss room will have a special door which you must pay two hearts to open, and leads to the 3rd alt floor, Mausoleum. Walk to the end of the path to get the 2nd knife piece. Press the buttons and then ride the minecart. Mines II has 3 yellow buttons somewhere on the floor, and a room with a minecart in it. The mirror world Item Room will have a knife piece. Touch the white fire to temporarily turn into The Lost, then walk thru the mirror to access the mirror world. The 3rd and 4th normal floors (and Downpour II) will have a barricaded door (requires 2 bombs) in the boss room which leads to the second alt floor, Mines.ĭownpour II has a white fireplace somewhere on the floor, and a room with a mirror in it. The first two normal floors of any run will now have a locked door (requires a key) in the boss room which leads to the first alt floor, Downpour. ![]() Hush is guaranteed to spawn this portal if you defeat him (check the top right corner of his boss room after defeating him).ĭefeat Hush 3 times to unlock the alt floors, which eventually lead you to Mother. You can get to the Void by going through a portal that is sometimes spawned when defeating various late game bosses. The Blue Womb can be found by going through a large door that is spawned by defeating Mom's Heart before the 30 minute mark in any run.ĭefeat Hush 1 time to unlock the Void floor, where you can fight Delirium. Do this twice in one run to get a full Key, then you can use it to unlock the Mega Satan door in the Dark Room or the Chest.ĭefeat Mom's Heart 10 times to unlock the Blue Womb floor, where you can fight Hush. This causes the statue to turn into a boss which you can kill for a Key Piece. Alternatively you can defeat Isaac while holding The Polaroid to progress to the Chest and fight ?.ĭefeating The Lamb or ? once will make it possible to blow up the angel statues that appear in angel rooms. Once The Negative / Polaroid are unlocked, you can defeat Satan while holding The Negative to progress to the Dark Room and fight The Lamb. Defeating It Lives will always spawn an entrance to both Sheol and Cathedral without needing to get a devil / angel deal. If you get a devil / angel deal from the Mom's Heart fight, you can go into the devil / angel room and progress to Sheol / Cathedral to fight Satan / Isaac.ĭefeating Mom's Heart 11 times will turn Mom's Heart into It Lives. I highly recommend all players use the External Item Descriptions mod so you don't have to manually look up the effect of every item you find.ĭefeat Satan 5 times to unlock The Negative and Isaac 5 times to unlock The Polaroid. Achievements can then be unlocked even with mods and the debug console enabled. Let me know if there's any other big progression milestones that I should include.ĭefeat Mom 1 time (without mods or the debug console enabled) to unlock the Womb floors and Mom's Heart. So I decided to make a quick(ish) guide, mostly for my future self tbh. I'm starting my 3rd save file and still can't remember how a lot of early progression milestones are unlocked, and it's super obtuse trying to find it on the wiki. SPOILER WARNING if you're a new player who cares about that kind of thing.
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